Cardiology · Rare-to-common · teaser
Updated August 2026 · TTR (wild-type + hereditary)
Teaser case. Selected price and peak-sales fields are held for a paid Brief — the rest is the method.
Model levers
Custom per indication. These sliders re-cut the published funnel — they do not invent a claims extract.
Funnel · US
Suspect pool (HFpEF / AS / LVH)420,000
Diagnosed ATTR-CM38,000
Wild-type31,000
Hereditary7,000
NAC 1 / NYHA I–II16,000
On disease-modifying Rx21,000
Editor-addressable (dir.)9,000
Genotype
Phenotype